PhD projects
"Translational model of Vascular Occlusive Crisis in anesthetized mice with Sickle Cell Disease" by Ariadna Carol Illa. Supervisors: Søren Skov, KU-SUND, & Carsten Dan Ley, Novo Nordisk. PhD fellowship initiated 15 April 2021.
"Mechanisms behind gut-liver-fat crosstalk in a humanized mouse model for diet induced metabolic disorders" by Penille Jensen. Supervisors: Camilla Hartmann Friis Hansen, KU-SUND, Axel Kornerup Hansen, KU-SUND & Jenny Norlin, Novo Nordisk. PhD fellowship initiated 31 December 2020.
"You are what your mother ate! – Foetal metabolic reprogramming in NAFLD and NASH" by Kamilla Pedersen. Supervisors: Pernille Tveden-Nyborg, KU-SUND & Jens Lykkesfeldt, KU-SUND. PhD fellowship initiated 1 August 2020.
"Assessment of immunotoxicity of stealthified induced pluripotent stem cells (iPSCs) for in vivo implantation in a porcine model" by Henriette Reventlow Frederiksen. Supervisors: Pernille Tveden-Nyborg, KU-SUND, Karla Kristine Freude, KU-SUND, Shamim H Rahman, Novo Nordisk & Ulrik Døhn, Novo Nordisk. PhD fellowship initiated 1 March 2020.
"In depth characterization of myocardial function in a porcine model of ischemic heart failure" by Karina Poulsdóttir Debes. Supervisors: Lisbeth Høier Olsen, KU-SUND, Thomas Jespersen, KU-SUND, Jeppe Egedal Kirchhoff, Novo Nordisk, Trine Pagh Ludvigsen, Novo Nordisk & Jacob Eifer Møller, Odense University Hospital. PhD fellowship initiated 2 December 2019.
"The role of the hepatic stellate cells in non-alcoholic steatohepatitis and fibrosis" by Alexandra Zisser. Supervisors: Pernille Tveden-Nyborg, KU-SUND, Markus Latta, Novo Nordisk & Jens Lykkesfeldt, KU-SUND. PhD fellowship initiated 1 November 2019.
"Platelet and myocardial function in a novel porcine model of hypoglycaemia" by Mille Lyhne Skøttrup. Supervisors: Lisbeth Høier Olsen, KU-SUND, Ulrik Pedersen-Bjergaard, KU-SUND, Andreas Vegge, Novo Nordisk, Rita Slaaby, Novo Nordisk & Gro Klitgaard Povlsen, Novo Nordisk. PhD fellowship initiated 1 March 2019.
"Progression and reversibility of NASH with hepatic fibrosis in vivo" by Josephine Skat-Rørdam. Supervisors: Pernille Tveden-Nyborg, KU-SUND, Jens Lykkesfeldt, KU-SUND & Markus Latta, Novo Nordisk. PhD fellowship initiated 1 July 2018.
"Establishment of a Haemophilia A model with increased tolerance by use of mice with deficiencies in adaptive immunity" by Gabi Overgaard Øvlisen. Supervisors: Søren Skov, KU-SUND, Thomas Lindebo Holm, Novo Nordisk, Peter Thygesen, Novo Nordisk & Kasper Almholt, Novo Nordisk. PhD fellowship initiated 15 May 2018.
"Causes of diabetic peripheral neuropathy in rodent models of type 1 and 2 diabetes" by Laura Jul Andreasen. Supervisors: Jens Lykkesfeldt, KU-SUND, Thorbjörn Åkerström, Novo Nordisk, Rikke Kaae Kirk, Novo Nordisk & Christian Fledelius, Novo Nordisk. PhD fellowship initiated 1 April 2018.
"Investigating the role of GLP-1 receptor activation in the gastropyloric region for stimulating intestinal mucosal defence and decreasing intestinal permeability" by Louise Pedersen. Supervisors: Axel Kornerup-Hansen, KU-SUND, Bidda Rolin, Novo Nordisk, Rikke Kaae Kirk, Novo Nordisk. PhD fellowship initiated 1 March 2017.
"Effects of GLP-1 on atherosclerosis, vascular functionality and remodelling" by Katrine Dahl Bjørnholm. Supervisors: Jens Lykkesfeldt, KU-SUND, Pernille Tveden-Nyborg, KU-SUND, Gry Freja Skovsted, KU-SUND, Günaj Rakipovski, Novo Nordisk, Gro Kligaard, Novo Nordisk. PhD fellowship initiated 1 April 2017.
"Development of a type 2 diabetic minipig model by increasing plasma levels of gut microbiota products" by Ditte Olsen Lützhøft. Supervisors: Axel Kornerup Hansen, KU-SUND, Rikke Bjerrring Skyggebjerg, Erik Max Wulff, Berit Ø. Christoffersen, Novo Nordisk. Dennis Sandris Nielsen, KU-Science. PhD fellowship initiated 1 November 2017.
"The effect of diet-induced obesity on differential metabolic responses in rats and mice" by Hannah Zakariassen. Supervisors: Jens Lykkesfeldt, KU-SUND, Linu Mary John, Kirsten Raun, Novo Nordisk. PhD fellowship initiated 1 March 2016.
"Factors driving the variation in absorption of subcutaneously administered insulins" by Anna Katrina Olsen. Supervisors: Jens Lykkesfeldt, KU-SUND, Hanne Refsgaard, Trine Porsgaard, Sanne Gram-Nielsen, Torben Seested Johansen, Novo Nordisk. PhD fellowship initiated 1 March 2016.
"In Vivo characterization of critical determinants of bleeding in the development of haemophilic arthropathy in the F8-KO rat" by Kåre Kryger Vøls. Supervisors: Axel Kornerup Hansen, KU-SUND, Mads Kjelgaard-Hansen, Kristine Roepstorff, Novo Nordisk. PhD fellowship initiated 1 August 2016.
"Effects of insulin treatment on NAFLD in diabetic rodents" by Victoria Svop Jensen. Supervisors: Jens Lykkesfeldt, KU-SUND, Christian Fledelius, Henning Hvid, Novo Nordisk. PhD fellowship initiated 1 September 2016.
"Investigating the role of FGF21 on hepatic oxidative stress and NALFD/NASH" by Julie Hviid Klæbel. Supervisors: Jens Lykkesfeldt, KU-SUND, Pernille Tveden-Nyborg, KU-SUND, Günaj Rakipovski, Novo Nordisk. PhD fellowship initiated 1 October 2016.
"Mechanisms of neuronal damage induced by vitamin C deficiency" by Stine Normann Hansen. Supervisors: jens Lykkesfeldt, Pernille Tveden-Nyborg, KU-SUND. PhD fellowship initiated 1 February 2015. Finalized April 2018.
"Characterization of the natriuretic peptide system in a dietinduced obese atherosclerotic minipig model" by Camilla Schumacher-Petersen. Supervisors: Lisbeth Høier Olsen, KU-SUND, Henrik Duelund Pedersen, Novo Nordisk, Nora Elisabeth Zois, Dept. og Clinical Biochemistry, Rigshospitalet. PhD fellowship initiated 1 March 2015. Finalized June 2018.
"Refining humane endpoints of long term studies: Using murine species-specific behaviours to assess reduced welfare in the home cage of mice and rats" by Karen Gjendal. Supervisors: Dorte Bratbo Sørensen, KU-SUND, Jan Lund Ottesen, Novo Nordisk, Anna Olsson, Inst. for molecular and cell biology, Portugal. PhD fellowship initiated 1 May 2015.
"Unraveling disease mechanisms in the diabetic heart" by Simone Krog Christensen. Supervisors: Lisbeth Høier Olsen, KU-SUND, Henrik Duelund Pedersen, Novo Nordisk, Jacob Eifer Møller, Odense University Hospital. PhD fellowship initiated 1 October 2015.
"Characterization of immune complex formation and elimination following administration of human antibodies to rats. Establishment of a possible correlation with pathological changes" by Lykke Boysen. Supervisors: Jens Lykkesfeldt, KU-SUND, Brian Lauritzen, Anne Ejrnæs Sprinkel and Johan Forsell, Novo Nordisk. PhD fellowship initiated 1 November 2015.
”The high fat fed guinea pig as a model for human dyslipidemia and pre-diabetes”, by David Høilund Ipsen. Supervisors: Jens Lykkesfeldt, KU-SUND, Bidda Rolin, Günaj Rakipovski, Novo Nordisk. PhD fellowship initiated 1 January 2014. Finalized March 2017.
"The impact of neonatal Fc receptor and disease processes on in vivo distribution of biopharmaceuticals using advanced imaging technologies", by Laura Kofoed Hvidsten Ørstrup. Supervisors: Jens Lykkesfeldt, KU-SUND, Peter Thygesen, Maj Petersen, Novo Nordisk. PhD fellowship initiated 1 May 2014.
"Characterization of diabetic nephropathy in a minipig model of dyslipidemia, hyperglycemia and hypertension", by Rikke Lindgaard Thomsen. Supervisors: Lisbeth Høier Olsen, KU-SUND, Henrik Duelund Pedersen & Berit Christoffersen, Novo Nordisk. PhD fellowship initiated 1 September 2014. Exmatriculated.
"Comparative analysis of zebra fish and rodent IBD disease models", by Simon Haarder. Supervisors: Kurt Buchmann, KU-SUND, Per Kania & Poul Hyttel, KU-SUND, Thomas Lindebo, Novo Nordisk. PhD fellowship initiated 1 January 2013. Finalized June 2017.
"Characterization of the immune respons to coagulation factor VII in a newly established haemophilia A rat; a model for studies on the mechanism of inhibitor formation in haemophilia A", by Karin Maria Löfgren. Supervisors: Søren Skov, KU-SUND, Bo Wiinberg, Novo Nordisk. PhD fellowship initiated 1 February, 2013. Finalized June 2017.
"Characterization of real time in-vivo coagulation and clot formation by fluorescence microscopy in haemophilia treatments", by Caroline Røddik. Supervisors: Jens Lykkesfeldt, KU-SUND, Christian Sommer, Novo Nordisk, Pernille Tveden-Nyborg, KU-SUND. PhD fellowship initiated 1 June, 2013. Finalized February 2016.
"The specificity of regulator cells in relation to Type 1 diabetes", by Pernille Kihl. Supervisors: Axel Kornerup Hansen, KU-SUND, Matthias von Herrath, Novo Nordisk Seattle, Karsten Buschard, Bartholin Institute. PhD fellowship initiated 1 June, 2013. Finalized.
"Cognitive and emotional consequences of diet-induced obesity in rats", by Alessandro Virtuoso. Supervisors: Dorte Bratbo Sørensen, Pernille Tveden-Nyborg, Bjørn Forkman, KU-SUND, David Alexander Sarruf, Novo Nordisk. PhD fellowship initiated 1 August, 2013. Finalized October 2016.
"Development and characterization of induced haemarthrosis in the FVIII knockout rat as a mode of haemarthrosis in human haemophilia A", by Kristine Rothaus Sørensen. Supervisors: Axel Kornerup Hansen, KU-SUND, Lise Nikolic Nielsen, Kirstine Roebstorff, Novo Nordisk, Søren Skov, KU-SUND. PhD fellowship initiated 1 November, 2013. Finalized February 2017.
"Predictive value of murine DTH Monoarthritis for rehumatoid Arthritis (RA)", by Sara Marie Atkinson. Supervisors: Søren Skov, KU-SUND, Anneline Nansen, Novo Nordisk. PhD fellowship initiated 1 March 2012. Finalized Dec. 2015.
"Relative importance of liver and kidney in the clearance of rFVIIa", by Bill Vestergaard. Supervisors: Jens Lykkesfeldt, KU-SUND, Henrik Agersø, Novo Nordisk. PhD fellowship initiated 1 March 2012. Finalized March 2016.
"New In Vivo cardiovascular biomarkers in an animal model of chronic mitral regurgitation", by Maria Josefine Reimann. Supervisors: Lisbeth Høier Olsen, KU-SUND, Jacob Eifer Møller, Rigshospitalet, Jens Häggström, SLU Uppsala, Sweden. PhD fellowship initiated 1 April 2012. Finalized August 2018.
"Metabolic changes induced in non-diabetic rats following chronic hyperinsulinaemic hypoglycaemia", by Vivi F.H. Jensen. Supervisors: Jens Lykkesfeldt, KU-SUND, Ingrid Bøgh Brück, Novo Nordisk. PhD fellowship initiated 1 April. 2012. Finalized October 2015.
"Inducing gut regulatory immunity in early life to treat or prevent inflammatory disease later in life", by Katja Maria Bangsgaard Bendtsen. Supervisors: Axel Kornerup Hansen, KU-SUND, Kirsten Dahl, Novo Nordisk, Kerstin Skovgaard, DTU. PhD fellowship initiated 1 June, 2012. Finalized June 2016.
"Microdialysis as a tool to determine drug concentration of infection sites in lung", by Lisa Amanda Holm Rottbøll. Supervisor: Christian Friis, KU-SUND. PhD fellowship initiated 1 June, 2012. Finalized September 2015.
"Effect and mode of action of liraglutide intervention on hyperglycaemia mediated oxidative stress in diabetic and diabetic complications animal models", by Karen Ekkelund Petersen. Supervisor: Jens Lykkesfeldt, KU-SUND, Kirsten Raun & Günaj Rakipovski, Novo Nordisk. PhD fellowship initiated 1 November, 2012. Finalized June 2017.
"Development and characterization of a diabetic and atherosclerotic rodent animal model", by Ida Rune Sørensen. Supervisors: Axel Kornerup-Hansen, KU-LIFE, Bidda Rolin & Berit Christoffersen, Novo Nordisk. PhD fellowship initiated 1/1 2011. Finalized.
"Neonatal vitamin C deficiency and impaired brain development: A dose-response study", by Stine Hasselholt Andersen. Supervisors: Jens Lykkesfeldt & Pernille Tveden-Nyborg, KU-LIFE . PhD fellowship initiated in 1 February 2011. Finalized.
"Development and characterization of an atherosclerotic minipig model", by Trine Pagh Ludvigsen. Supervisors: Lisbeth Høier Olsen, KU-LIFE, Henrik Duelund Pedersen and Berit Ø. Christoffersen, Novo Nordisk. PhD fellowship initiated 1 July 2011. Finalized.
" The piroxicam accelerated colitis model in IL-10k.o. mice as a tool to discover and characterize novel therapeutics in IBD", by Kristine Holgersen. Supervisors: Axel Kornerup Hansen, KU-LIFE, Thomas Lindebo Holm and Helle Markholst, Novo Nordisk. PhD fellowship initiated 15 Sept. 2011. Finalized.
"Applicability of chronic inflammation models for mechanistic in vivo studies", by Anne Deen Christensen. Supervisors: Søren Skov, KU-LIFE, Claus Haase, Novo Nordisk. PhD fellowship initiated 15 Dec. 2010. Submitted 14 Dec. 2013. PhD defence: 28 April 2014. Finalized.